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Furthermore, it is difficult to identify specific pairs of proteases and substrates because numerous cleavage events occur simultaneously in cells.
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These cleavage events produce intermediate as well as final cleavage products that together with host factors initiate replication complex formation.
This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
Although this cleavage should happen specifically at the enzyme's recognition sequence, an unknown proportion of cleavage events may involve other sequences, owing to the enzyme's star activity or to random DNA breakage.
Third, with intact hemoglobin, numerous cleavage products were identified.
Pattern analysis of cleavage events indicated putative targeting sequences during the GV-MII transition.
Two LSU rRNA fragments appear first, followed by smaller fragments produced by additional cleavage events.
No such cleavage events were observed in 8226 GFP cells.
Ribosome biogenesis involves a number of pre-rRNA cleavage events.
GZMB incubation resulted in production of numerous cleavage fragments ranging in size from approximately 15 55 kDa.
Numerous cleavage nuclei begin to penetrate the periplasm about 10 h after oviposition.
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