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However there are numerous challenging issues to be addressed before detailed elucidation of epigenetic regulatory roles of mA in RNA metabolism.
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Optimization with nonlinear constraints is a numerically challenging issue.
Because of the numerous and challenging issues in CNS drug discovery and the low success rates, pharmaceutical companies are beginning to deprioritize their drug discovery efforts in the CNS arena.
By considering the maximum stress measure in the global and local forms, respectively, the STM (stability transformation method -based stress correction schemethod -basedolated stresshancorrection measchemere developed to tandle the challenging issues from numerous local stress constraints and highly nonlinear stress behaviolated
Several challenging issues in the numerical solution are addressed.
In their numerous chemical forms, cellulose and various other biodegradable materials can be possible alternatives to resolve these challenging issues.
"We've had some challenging issues," Mr. Pease said.
There remain challenging issues, however, such as elephant rides.
There were lots of important and challenging issues".
Security of MANET is one of the challenging issues.
There are some challenging issues involved in this data set.
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