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These modules are commonly characterized of cysteine rich domains and are highly interactive with numerous cellular factors, such as such as fibronectin and heparin sulfate proteoglycans, extracellular signaling molecules, and cell surface proteins (Holbourn et al. 2008).
Because both LMB and CHX affect numerous cellular factors that are not specific to NF-κB, we attempted to minimize pleiotropic effects and cytotoxicity by eliminating pre-incubation and by using low drug concentrations (5 nM LMB and 2.5 µg/ml CHX).
Numerous cellular factors have been associated with the apoptotic signaling pathway.
Hypoxia is an element of the tumour microenvironment that impacts upon numerous cellular factors linked to clinical aggressiveness in cancer.
100 Evidence suggests that resveratrol inhibits numerous cellular factors that are involved in the initiation, promotion, and progression of cancer.
The assembly and budding process of enveloped viruses utilizes numerous cellular factors to facilitate transport from one membrane bound compartment to the other.
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Besides its role in DNA repair, APE1Ref-1 also functions as a redox activator of numerous cellular transcription factors, such as AP-1, NF-кB, p53, Egr-1, c-Myb, HIF-1α, HLF, and Pax-8, that are thought to be important in carcinogenesis [ 11].
Gene expression and its regulation involve a network of numerous cellular processes and factors involved in them.
A critical event in the fasting response is its metabolic adaptations and the liberation of fatty acids from adipose tissue governed by numerous endocrine and cellular factors.
The ERKs in turn phosphorylate numerous cellular proteins including transcription factors and thus have a central role in propagation of mitogenic signals.
Each person has ∼1 million pancreatic islets, which he described as multicellular organelles with complex interactions of nutrients, growth factors, neurotransmitters, and incretins regulated by numerous cellular receptors and nuclear receptor transcription factors.
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