Sentence examples for numerous cellular effects from inspiring English sources

Lysophophatidic acid is a simple phospholipid with numerous cellular effects including growth promotion, cell cycle progression and cytoskeletal organisation (Mills and Moolenaar, 2003).

Our findings demonstrate that under normal conditions (complete media) disulfiram selectively increases intracellular zinc in breast cancer cells and this may have numerous cellular effects with some leading to toxicity.

In this review, we describe the important potential of DHA to preserve neuronal and brain functions and classified its numerous molecular and cellular effects from impact on membrane lipid content and organisation to activation of signalling pathways sustaining synaptic function and neuronal survival.

These reports indicate that propionate can contribute to energy homoeostasis through effects on numerous cellular metabolic pathways and receptor-mediated mechanisms and provide a potential explanation for the differences in body weight gain and adiposity observed between supplementation groups in the long-term study.

Both of these effects can influence numerous cellular processes linked to ageing and the development of age-related disease [ 14].

TGF-β is a complex and pleiotropic cytokine with numerous cellular functions, including pro and anti-inflammatory effects that depend on the context of its activation 16, 33, 41.

The formation of focal complexes, focal adhesion and other integrin-related cellular structures has a profound effect on cell shape and numerous cellular processes that govern the biology of a cell [ 12].

As2O3 acts on cells through a variety of mechanisms, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects that include apoptosis induction, growth inhibition, promotion or inhibition of differentiation, and angiogenesis inhibition [ 23, 24].

Those are considered to be the key effect of proteases on apoptosis through the degradation of numerous cellular substrates including the cleavage of PARP.

The increase in intracellular LIP in oxidative stress conditions such as short exposure to H2O2 and the damaging effect of iron-catalysed oxidative damage has been shown in numerous cellular and animal studies [19 27].

As HDACs regulate numerous cellular pathways in addition to those listed here, it is likely that the protective effect of SAHA is due to modulation of multiple signaling pathways.