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Numerous cellular and molecular interactions have been identified by which immune cells can intervene in the metastatic cascade, leading to the development of several in vivo and in vitro model systems that can recapitulate these processes.
Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immune abnormalities.
The outcome of an immune response in vivo, however, is not solely determined by a single effector function of a specific cell population, but is the result of numerous cellular and molecular interactions that occur in the complex environment of intact organ systems.
Polyamines mediate numerous cellular and physiological functions.
TSP-1 is a matrix glycoprotein with diverse roles in numerous cellular and physiologic processes [7].
Alternative splicing plays an important role in numerous cellular and developmental processes such as cell growth and differentiation, cell signaling, programmed cell death, and nonsense-mediated decay [8], [9].
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Vascular hyporesponsiveness to vasopressors is a significant and independent prognostic factor of mortality involving several mechanisms and numerous cellular pathways and for which there is no new efficient and safe targeted therapy.
The tumor suppressor gene TP53 encodes a transcription factor controlling numerous cellular growth and signaling pathways, and thus it has been entitled the safeguard of genome integrity.
EGFR has been demonstrated to phosphorylate and regulate numerous cellular proteins and to initiate several signal transduction cascades, which lead to cell proliferation, migration, invasion, metastasis, angiogenesis and inhibition of apoptosis.
Iron is an essential cofactor for several proteins and enzymes and, therefore, involved in numerous cellular functions and metabolic pathways [ 50].
In the circulation, an interaction between breast tumor cells and platelets, leukocytes, and endothelial cells occurs through numerous cellular proteins and receptors (reviewed in [ 9]).
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