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Store-operated calcium channels (SOCs) are a nearly ubiquitous Ca(2+) entry pathway stimulated by numerous cell surface receptors via the reduction of Ca(2+) concentration in the ER.
Intracellular SRC-family kinases relay growth signals from numerous cell surface receptors and can be constitutively activated by oncogenic mutations, as can transmembrane growth factor receptors such as epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) that signal via their tyrosine kinase activity.
Recent studies of the mouse epithelial hierarchy have incorporated numerous cell surface markers to characterize specific epithelial populations.
SHP-2 functions downstream of numerous cell surface receptors to regulate diverse cellular responses, including growth, survival, proliferation and differentiation.
Wands et al. now reveal that numerous cell surface molecules are recognized by CTB, and that these molecules can assist cholera toxin uptake by host cells.
The posterior subcapsular regions of 5 wk and 54 wk alphaA/BKO lenses were filled with irregularly shaped cells with numerous cell surface projections.
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Numerous cell-surface markers are known to proliferate in human solid tumor.
Grb2 is a multi-domain protein that functionally integrates signals from numerous cell-surface receptors and its absence leads to early embryonic lethality [53].
We could find a signature defining T cells that contained numerous cell-surface markers (e.g. TCA@, CD2, CD3G, CD6, IL2RB, IL2RG, IL7R, IL21R and ICOS), signaling genes (ZAP70, LAT, LCK, ITK) and cytotoxicity-related genes (GZMA, GZMB, GZMH, GZMK and PRF1).
The in silico interactomics analyses confirmed that, based on molecular profile of HBEC-EMVs, they could engage in numerous cell-surface interactions with both astrocytes and neurons.
Numerous cell-surface proteins are shed by a mechanism that involves metalloproteases, particularly the matrix metalloproteases and members of the ADAM family of proteins.
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