Enhanced expression was lost following growth to the blastocyst stage in the absence of inhibitor, though by this stage overall expression had fallen several-fold, presumably due to silencing of these two genes in the trophectoderm, the most numerous cell population in the blastocyst (Fig. 1C).
The mammalian lung is a complex organ containing numerous putative stem/progenitor cell populations that contribute to region-specific tissue homeostasis and repair.
We next proceeded to cryopreserve large panels of combinatorial encoded MHC multimers, i.e., mix of two differently labeled pMHC multimers holding the same peptide sequence, to be used for parallel detection of numerous T-cell populations (16).
Cellular senescence is a terminal phase observed towards the end of a primary human fibroblast cell population after numerous cell divisions; it is considered to be the cellular aging process.
Alone, CD90.2 stains numerous cell types including thymocyte populations, neurons, epithelial cells and subsets of fibroblasts [ 42].
Tissue engineering approaches for expanding, differentiating and engrafting embryonic or adult stem cells have significant potential for tissue repair but harnessing endogenous stem cell populations offers numerous advantages over these approaches.
For example, the magnitude and reproducibility of the response to selected mutagens could be assessed for cell populations derived from numerous animals, including very young animals (e.g., 14 days), as well as animals exposed to chemical inducers of liver enzymes (e.g., Aroclor).
Unfortunately, myeloma cells are a heterogeneous population that express numerous cell surface antigens, including CD38, CD45, CD138, and adhesion molecules like VLA4 [ 13].
Recent studies of the mouse epithelial hierarchy have incorporated numerous cell surface markers to characterize specific epithelial populations.
NSCs, with their permissive state of differentiation, would need much fewer molecular transformational events, whereas mature cell populations would require more numerous alterations (Gisselsson 2007).
