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Although these findings were first observed in isolated rat hepatocytes, similar results have since been obtained in numerous cell models including primary human hepatocytes [ 13].
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HER2 overexpression is potently transforming in numerous cell culture models and in numerous transgenic mouse models (Moasser, 2007a).
In breast cancer, numerous cell culture models have shown PPARγ ligand activation induces differentiation and inhibits proliferation[ 45, 51].
This inclusion/aggregate pathology has also been observed in transgenic mice (7– 9), knock-in mice (10– 12) and numerous cell culture models (13– 13).
Apoptosis is largely mediated by the tumor suppressor gene p53, and numerous cancer cell models indicate that chemosensitivity is positively correlated with the induction of p53.
MC3T3-E1 cells have been extensively used in numerous cell culture experiments as a model for osteoblasts [36].
Although this phenotype can depend on the cell type, some mutations affecting this state are observed in numerous cell types and reproduced by our model; for instance, the senescent arrest arises from overexpression of p16INK4a [ 4, 7] and its abrogation from p21 or p16INK4a inactivation [ 7].
It has been used on numerous cell types and has applied a variety of modeling techniques [ 10].
However, solar cell models have a non-linear form with numerous parameters.
Since that time, numerous miRNAs have been found to interact either directly or indirectly with EMT machinery in several cell models [43].
However cell culture models cannot reproduce the injurious stimuli experienced in vivo, which is a combination of the initial stimulus (ventilation, hypoxia, pneumonia) and the coordinated inflammatory response of numerous cell types, including epithelial cells, macrophages, and neutrophils.
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