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Human bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into numerous cell lineages, making them ideal for tissue engineering.
IFN expression is induced in numerous cell lineages, including macrophages and plasmacytoid dendritic cells, by bacterial components such as LPS and CpG DNA [ 44- 46].
Numerous cell lineages of the hematopoietic system (with the notable exception of T-cells), as well as progenitor cells, utilize Lyn in complex signaling pathways, often through regulating receptor and/or integrin initiated networks.
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The major advantages of this method are 1) it uses a drug which has been approved for clinical application by the FDA, and 2) the drug can be used for not only hiPSC-derived CMs but also numerous other cell lineages derived from hiPSCs.
At the time of their seminal discovery, however, Mosmann and Coffman [ 10] predicted that more Th-cell subsets exist, and indeed numerous Th cell lineages have since been identified.
In fact, this niche environment has been associated with regulating key stem cell functions, such as maintaining stem cell quiescence and providing proliferation- or maturation-inducing signals when numerous progenitor cells are required to generate mature cell lineages.
As expected from the Tbx18-Cre lineage trace data, pericytes were the most numerous cell type in these clones.
Macrophages, one of the phagocytic cell lineages presented in most tissues, contribute to the innate immunity and are responsible for numerous inflammatory, immunological, and metabolic processes [ 5].
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.
The T cell repertoire comprises αβ and γδ T cell lineages.
Herrera, P. L. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages.
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