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Due to the existence of numerous cell death modalities, the precise identification and characterization of cell death-related events in cells and tissues is critical for understanding disease pathogenesis and designing effective therapeutic strategies.
Inhibitor of apoptosis proteins (IAPs) are important regulators of apoptotic and necroptotic cell death mediated by numerous cell death signalling platforms.
Previous genetic studies in Drosophila have identified numerous cell death regulating genes, providing new insights into the mechanisms for related diseases.
The localisation of PTP1B to the ER and mitochondrion positions it as a potential mediator of numerous cell death signals as well as potential roles in the regulation of redox metabolism.
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With the progression of chondrogenesis, decreased miR-9 level was observed at the time of numerous apoptotic cell deaths.
Direct intracardiac cell injection for heart repair is hindered by numerous limitations including: cell death, poor spreading of the injected cells, arrhythmia, needle injury, etc. Tissue-engineered cell sheet implantation has the potential to overcome some of these limitations.
Numerous types of cell death have been described in diverse tissues and organs.
Especially, ASM-generated ceramide has been well investigated in numerous types of cell death.
The cleavage of chromatin into oligonucleosomal fragments, which form the characteristic apoptotic DNA ladder, has been documented in numerous models of cell death.
While numerous probes for cell death are available in vitro, targeting various stages of the apoptotic process, a barrier currently exists in their use in vivo.
Their role may be in conflict with specific methyltransferase genes by cleaving methylated genomic DNA at numerous sites to cell death.
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