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Quantitative RT-PCR analyses revealed significant changes in the expression of numerous cell cycle genes (Fig. 4 A ).
In our study, a decrease of expression levels occurred very early in response to T in numerous cell cycle genes.
Numerous cell cycle genes have been identified with AhR activation such as PAI-1 and SOS (Huang and Elferink 2005 ; Pierre et al. 2011 ).
It has been demonstrated that the depletion of polyamines can lead to cell cycle arrest or apoptosis by affecting numerous cell cycle regulatory pathways [ 34].
Continued studies of how NF-κB can directly regulate expression of numerous cell cycle related genes is warranted, given these findings.
Although SKP2 targets numerous cell cycle regulators for ubiquitination and degradation, the oncogenic potential of SKP2 is mainly linked to p27 degradation, as evidenced by low levels of p27 in aggressive tumors in which SKP2 expression is high.
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This occurs due to alterations of a gene expression status of relevant genes in a specific cell type, which is then inherited through numerous cell cycles.
Unlike neural progenitor cells, however, BCPCs do not become postmitotic and differentiate in a controlled way, but continue to divide for numerous cell cycles and grow a tumor mass.
AUF1 is a well-known RNA-binding protein that promotes degradation of ARE-containing mRNAs encoding numerous cytokines, cell cycle regulators, and other inflammatory molecules.
ROCK activity is necessary for progression from G1 to S-phase by controlling the expression of cyclins, CDKs, and numerous other cell cycle regulators [ 33].
Recently, the centrosome has also been recognized as major docking station where regulatory complexes accumulate including kinases and phosphatases as well as numerous other cell cycle regulators that utilize the centrosome as platform to coordinate multiple cell cycle-specific functions.
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