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To evaluate optic disc drusen, extracellular protein deposits known to contain numerous aggregates of mitochondria, using multimodal modalities featuring optical coherence tomography (OCT) and autofluorescence imaging.
With bacterial colonization and biofilm development, numerous aggregates of bacteria and some algal cells embedded in an amorphous organic matrix were formed on and within the Tuff grains.
Both thalamus and diencephalon displayed numerous aggregates, most of which were interspersed within neuronal fibers.
The intronic AUUCU repeat mutation is properly spliced out but becomes resistant to degradation and is deposited as numerous aggregates in nuclei and cytoplasm in SCA10 cells.
The motoneurons thus showed two types of misSOD1 staining: either intranuclear staining in motoneurons or a perinuclear misSOD1 staining with numerous aggregates of misfolded SOD1 in the soma but no sign of intranuclear staining (Fig. 2e).
In families 1 and 2, the staining pattern was characterized by numerous aggregates of small size (<0.5 μm) (Fig. 2C), suggesting a mutation affecting the motor domain of myosin-9 [2,4].
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Numerous aggregate properties were measured for all aggregate sources.
Pores (marked by an arrow) in the membrane of the untreated erythrocyte (D) and adhesion of a larger TiO2 aggregate (E, black arrow) and of numerous ZnO aggregates (F, white arrow) could be observed.
This is because of the time-consuming process when modeling the actual specimen which was composed of numerous coarse aggregates with various shapes.
Ocular pressure was normal, and fundus examination showed a mild diffuse hyalitis with numerous vitreous aggregates (at the top of the macula and along the vessels) overlying a yellowish macular lesion estimated at two papillary diameters.
Less numerous larger aggregates, between 8 000–18 000 µm2, were also observed (Figs. 2E and F).
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