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Numerous abnormalities, including fibrosis, abnormal wound healing, defective cardiac remodeling, tumor metastases, aberrant angiogenesis and ectopic calcification, have been observed in Spp1 KO mice.
They find that npc1 morphants display numerous abnormalities, including cholesterol mislocalisation, cell-movement defects and, at later stages of embryogenesis, cell death.
This article is the first to describe the induction of numerous abnormalities, including both benign and malignant lesions, in reproductive tissues of aged female mice exposed prenatally to a broad range of BPA doses (0.1 1,000 μg/kg maternal body weight).
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zMELK likely plays an essential role in organogenesis, as disrupted zMELK expression by Morpholino injection resulted in numerous developmental abnormalities including severe anemia, retarded eye development, a swollen cerebral tectum, and a slower heart rate.
In agreement with previous reports, Lexicon's Dkk2 KO mice had numerous ocular abnormalities, including a lack of Harderian glands and malformed eyelids.
Although numerous genetic abnormalities, including MYCN amplification, are associated with tumour progression and poor outcome, the molecular mechanisms responsible for the pathogenesis of aggressive neuroblastoma remain unclear.
A 28-month female with a clinical diagnosis of neurocutaneous melanosis and numerous intracranial abnormalities (including a right choroid plexus tumor and left hemimegalencephaly) presented with a rapidly expanding tumor in the left occipital cerebrum.
There have been numerous reports of associations between SCZ and chromosomal abnormalities including fragile sites, reciprocal translocations, inversions, insertions, deletions, disomy and trisomy in many autosomes, and sex chromosome aneuploidies [ 141].
Numerous preclinical studies have now demonstrated that these strategies have the potential to mitigate several aspects of the neuropathology and behavioural abnormalities (including cognitive decline) characteristic of various animal models of these disorders while also promoting neurogenesis.
Shortage of vitamin D3 can also cause physical abnormalities, including a soft or overgrown beak, splayed legs, and bent keels.
One patient had midline abnormalities, including bilateral optic nerve hypoplasia.
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