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While the qRT-PCR analysis yielded a copy number readout for every cell line, an arbitrary "zero" cut-off for prostasin mRNA expression in the data presentation was set with the KU-7 cell line, which does not express detectable levels of the prostasin protein.
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The same sliding windows were used in averaging the copy number readouts from the MCF-7 aCGH data, which was used as the benchmark in the MCF-7 study.
In this analysis we used both infection index and cell number readouts.
The cell number readouts (see Additional file 1: Figure S4) showed qualitatively similar results for data reproducibility.
The total number of readout channels amounts to 9600.
However, this results in a high number of readout channels and electronics, resulting in increased power consumption.
A PDC capable of reducing the number of readout channels by a factor of 32 was designed and fabricated.
A fundamental challenge for PET block detector designs is to deploy finer crystal elements while limiting the number of readout channels.
In order to reduce the number of readout lines, we introduce a new encoding scheme, the Global-Local Grouping (GLG) method.
The large number of readout channels drives the front-end electronics design toward low power devices with the additional requirement of a large dynamic range.
The PoST is motivated by the desire to achieve a larger field-of-view without increasing the number of readout channels.
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