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The number one harm reduction tip for cannabis is to not smoke it with tobacco".
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MR: So the number one record might have done more harm than good for NRBQ?
One harm is excess tests, like biopsies.
How might one harm a child through choosing genetic traits?
Number one!
Thankfully, no one harmed them physically.
Become number-one in something.
The numerical difference observed in this study can be interpreted into the number needed to harm for one additional death, which was estimated to be 108 patients.
Compared with previous studies, our population with impaired glucose tolerance has a smaller number needed to harm, with one case of new onset diabetes for every 12 patients treated over five years; whereas in a population with non-impaired glucose tolerance, the number needed to harm has been as high as 255 over four years.
Our non-inferiority margin was considered clinically reasonable, because the resulting minimum number needed to harm of one in 10 (that is, a 10% difference between groups in major flare) seemed a fair trade-off when considering that the expected number needed to benefit was lower than one in two (that is, 50% difference between groups in successful dose reduction or stopping).
5 In view of an average rate of overall mortality of 12% over four years observed in people with diabetes, 1 this hazard ratio would translate into a number needed to harm to cause one death over four years as low as 4 (95% confidence interval 2 to 22).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com