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Overall, the mean (±SD) number of titrations for nicardipine was 2.7±1.59 vs 1.4±1.0 (p<0.001) for labetalol.
A report from a workshop on two-phase titrations involving a large number of titrations of 18 concluded that the ion pair form does not partition into octanol.
Overall, the mean (±standard deviation) number of titrations for nicardipine were 2.2 ± 1, and the mean number of doses of labetalol were 1.3 ± 0.97 (P < 0.001).
A larger number of titrations are shown here than in panel A to prevent panel A from being overcrowded; each fold-increase was determined by a full stoichiometric titration where each titration was completely and fully saturated.
The fold-increase in Figure 3B is from the amplitude from the titrations performed in Figure 3A; however, a larger number of titrations were performed than are represented in 3A in order to prevent 3A from being overcrowded.
To achieve maximal clinical efficacy we found the most common number of titrations was 2 with an increasing proportion of patients on 37.5 and 50 mg dosages during the time-course of the study.
The greater ability of rosuvastatin to lower LDL-C was also reflected by the number of dose titrations required by each treatment group; a total of 75 titration steps were required by rosuvastatin-treated patients compared with 155 titrations in the atorvastatin group.
There were a substantial number of such unreliable titrations: 35% of the positives and 70% of the negatives for which an AC50 was obtained.
Each reporter plasmid offers a balance between maximizing the fluorescence for high sensitivity and minimizing the copy number to limit titration of the transcription regulators AraC and XylR.
The number of up to 100 titration points was attained by volume increments 5.0 μL.
This numerical value is in agreement with our other determinations of the number of aggregation employing isothermal titration calorimetry and data analysis of the molar conductivity dependency with concentration of the solute.
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