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However they only investigated designs where the number of dose levels was at most 20.
Since the number of dose levels are important for model selection study design is important and should be further evaluated.
In addition, we estimated the number of dose and duration of intravenous bisphosphonate at the time of occurrence of AFFs.
They include guidance on the main group size, the inclusion of recovery groups and the number of dose groups used in short and long term chronic toxicology studies.
Some examples include minimizing the number of dose groups, the number of animals per group, and the inclusion of recovery animals.
A number of dose reduction strategies are available, such as tube current modulation and alteration of the tube current and voltage dependant on the patient's body mass index [40] and more recently iterative reconstruction techniques [41].
An extension of the continual reassessment method using a preliminary up and down design in a dose finding study in cancer patients in order to investigate a greater number of dose levels.
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To help mitigate this effect, a number of dose-saving steps can be taken.
Despite administering HDLEN at doses of up to 350 mg/day, the maximum tolerated dose could not be determined, owing to an insufficient number of dose-limiting toxicities in the 21 patients enrolled in the trial.
At the same time, fingolimod manifests a number of dose-dependent adverse events.
The median number of dose-levels explored was 5 (range, 2 12).
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