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Phase I studies have determined the maximum tolerated dose (MTD) of capecitabine and identified a number of dosage regimens, which were subsequently evaluated in a randomised, phase II study as first-line treatment for metastatic colorectal cancer.
The median number of dosage adjustments to attain normal concentrations was 1 (range 0-4 adjustments).
Lohman et al. [9] report that 12.5% of triptan users utilized more than one drug product and received 25% of the total number of dosage units.
The estimated value of the ApEn (m,r,N) depends on m the pattern length used for prediction of the subsequent value, r the level of noise filtering, and N the number of dosage values in the run to be compared.
Type and number of dosage units purchased per outlet.
Subsequently, TTU linearly increased with a higher number of dosage omissions with comparable slope.
Similar(43)
Many patients suffering from developmental disorders harbor submicroscopic deletions or duplications that, by affecting the copy number of dosage-sensitive genes or disrupting normal gene expression, lead to disease.
This ultimately exposes the patient to drug only when required, reducing the number of dosages, reducing side-effects and increasing patient compliance.
This number, as we explain above, is likely to significantly underrepresent the actual number of dosage-compensated networks.
As the number of surveyed genomes increases, we predict that the number of dosage-insensitive genes in the shared single copy list will steadily decrease.
The addition of this analysis allowed us to substantially expand the number of dosage-compensated genes identified, bolstering in the statistical power throughout the paper.
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