The current document includes a number of consensus points reflecting the design of phase II/III clinical trials.
The merit of this method lies in that it, unlike the first one, does not require an infinite number of consensus iterations for a guaranteed performance.
eNote that the convergence rate calculated here is for the period of J k ≤ j ≤ J, where J ≫ 1 is the number of consensus iterations.
However, these results were not satisfactory, since for 50%% of the targets, the number of consensus molecules, thus the number of molecules to be tested experimentally, was equal to zero and consequently, no actives could be found.
Consensus updates are performed between every two tracking updates, where 0 ≤ j < J denotes the consensus iteration number, and J is the number of consensus iterations per tracking update (assumed to be fixed).
For each protein target, the number of consensus molecules (nCM corresponding to the number (n test ) of molecules to be tested experimentally in a real situation was different, ranging from 0 to 29, depending on the target.
In the latter case, to obtain the required number of consensus molecules, an iterative search is performed, starting from (x = 3.5) and decreasing x by 0.001 until the fixed nCM = n test is reached.
Instead, the number of consensus molecules nCM (which is equivalent to n test ) is decided by the user, and the SD multiplier x is varied to achieve the expected nCM.
To use juvenile dermatomyositis (DM) survey data and expert opinion to develop a small number of consensus treatment protocols, which reflect current initial treatment of moderately severe juvenile DM.A consensus meeting was held in Toronto, Ontario, Canada on December 1-2 , 2007
The three criteria, (T_{h > 0}), (leftlangle {Y_{C} } rightrangle) and Δp, showed that for any number of consensus molecules between 1 and 50, vSDC based on Gold, Glide, Surflex and FlexX performs better than any of these isolated programs (or similarly, only in the case of Gold, for (T_{h > 0}) in the range of (n_{test}) between 20 and 50).
For instance, for the dihydroorotate dehydrogenase (Pyrd in the DUD-E nomenclature), the number of consensus molecules was equal to 5 and they all happened to be active; we then considered the 5 top-ranked molecules of each program and counted the number of hits among them.
