Suggestions(1)
Exact(6)
Due to the limited number of conjugation sites and the distinct reactivity of the thiol group, cysteine-based conjugation is superior to lysine-based conjugation in terms of controlled DAR and heterogeneity.
The use of dendrimer as a platform enables synthesis of a broad range of particle sizes, however, the payload of Gd that can be delivered is limited by the number of conjugation sites available on the dendrimer.
Quantum chemical calculations demonstrate a reduced number of conjugation sites for iso-sinapyl alcohol compared to sinapyl alcohol.
Five genes are ENIGMA-specific, 6 are SAMBA-specific and strikingly, 11 are ISA-specific, although ISA identifies the least number of conjugation genes in total and has the 'worst' top module.
Besides the described general findings regarding the negative influence of a high number of conjugated labeling moieties on the biodistribution properties of derivatized antibodies, one study systematically investigated the influence of the number of conjugation sites on the biodistribution of dual-labeled antibodies [ 55].
So far, there are no data indicating that modification of the glycans at N297 is problematic, but other methods such as THIOMAB, unnatural amino acid incorporation, and peptide tag methods provide flexibility in the number of conjugation sites and their placement that glycoconjugation does not.
Similar(54)
where and refer to the appropriate order and number of conjugations for the stage.
Different results are obtained according to the number of conjugations in the lag-product (10): (i)When no conjugation or two conjugations are used in the lag-product, the partition gives for its single element, so that.
Different results are obtained according to the number of conjugations in the lag-product (10): (i) When no conjugation or four conjugations are used in the lag-product, the first partition gives for its single element, and the three last partitions ; and give for their two elements, so that.
This technique allows better control over drug conjugation due to an increased number of possible conjugation sites on the mAb.
Co-conjugation of a replicative pSC101 vector carrying an ampicillin resistance gene was used to estimate the total number of conjugants.
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