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Chromosome copy number aberrations, anueploidies, are common in the human population but generally lethal.
Beyond mutations, efforts should be made to include recurrently methylated CpGs and copy number aberrations in such panels.
Future work should refine our initial panel to include recurrent copy number aberrations and hyper-methylated promoter regions.
Lung cancer specimens display recurrent copy number aberrations in distinguished chromosomal regions as compared with normal lung cells.
We identify altered pathways differentially targeted by copy number aberrations.
All samples assayed showed DNA copy number aberrations and LOH (Figure 1).
Copy number aberrations in MIFT can be detected by commercial tests.
Parental and PPP tolerant cell lines were identical in the majority of copy number aberrations detected.
One way of doing this is to undertake a pathway analysis to link the genes in various copy number aberrations.
DNA copy number aberrations would be expected to be retained throughout the life history of a cancer cell.
Furthermore, tumor samples typically contain normal cells that contaminate the tumor DNA, thus altering the amplitude of copy number aberrations.
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