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Each column represents an individual patient, colour-coded based on copy number aberration (amplification or deletion) and/or mutational state (truncating mutation, inframe mutation, missense mutation) across profiled oncogenes and suppressors frequently altered in lung adenocarcinoma.
Therefore there was no single copy number aberration distinguishing this class.
Overall, 112 genes exhibited copy number aberration in 50 or more tumors.
The normalization and detection of copy number aberration is detailed in Methods S1.
As one would expect, we detected many regions that exhibited copy number aberration in each of the tumor cell lines.
One goal of SNP array studies is to detect the regions of Copy Number Aberration (CNA) in the whole genome.
Genes in the final analysis were merged with methylation data and identified copy number aberration regions according to genomic locations.
Our data are correlative in nature, and do not rigorously establish a link between methylation status or copy number aberration in cell lines and expression in tumors.
Our in silico analyses have identified a number of candidates including genes with evidence of both copy number aberration and mutation.
Copy number aberration may be involved, but our data suggest that only a few genes are likely candidates for ER-specific amplification or deletion.
Copy Number Aberration (CNA) in myelodysplastic syndromes (MDS) study using single nucleotide polymorphism (SNP) arrays have been received increasingly attentions in the recent years.
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