Sentence examples for numb activation from inspiring English sources

These results indicate that the Wnt/ β-catenin axis has a direct effect on NUMB activation and Notch signalling inhibition, consequently promoting GBM cells differentiation.

10.7554/eLife.01460.024 Figure 4. Downregulation of NUMB and activation of NOTCH signaling by pre-miR-146a/C and pre-miR-146a/G.

The balance between these cell-fates may be regulated by the level of Numb and the activation of Bmp15 and Nrg3 signalling pathways.

In the absence of HGF stimulation or Src activation, Numb interacts with both the Par complex through binding to Par3 and the cadherin complex through E-cad in MDCK cells.

PP2A, like Polo, acts to prevent excess neuroblast self-renewal primarily by regulating asymmetric localization and activation of Numb.

For example, Siah1, which belongs to the E3 ubiquitin ligase complex, is known to promote degradation of Numb, and thereby leads to activation of Notch [68] [71].

These effects were independent of changes in Numb protein levels and Notch activation.

We identify a role for the known Notch target Hes1, but surprisingly find that its induction is independent of Numb protein levels or Notch activation.

However, the correlation between Notch activation and loss of Numb needs to be examined in a larger group of patients as a recent study of 36 IDC cases failed to demonstrate a direct correlation [ 13].

Here we assessed whether emotion contagion scores were inversely related to the activation difference between intensity-rated numbed and non-numbed trials.

Importantly, this emotion regulation strategy is not only potentially lethal, but flattened and numbed emotional expressions secondary to DVC activation, as reviewed above, are posited to exacerbate social ostracism (see other examples below).