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Then, we compared the null pattern with that of the 1951 epidemic.
(B) Predicted null pattern of isolation by distance predicted in systems with limited gene flow, but limited selection.
In all these 7 tumours, the TP53 allele was hemizygous except in 1 intramucosal cancer (#M12) with a heterozygous pattern for an exon-8 mutation and a diffuse or a null pattern for p53, as indicated by immunohistochemistry.
The authors do an excellent job going over the different possibilities that could explain this null pattern of outcomes, even if they do not have much basis to rule out any of the hypotheses in particular.
Similar(56)
Similarly, null patterns were observed for all subtypes.
For the 75 null patterns considered in this simulation study, there were 23 patterns where the two tests had significantly different false-positive error rates.
There were 670 unique null patterns (indicating a meaningless response) identified, resulting in 33,591 of the open-ended responses (54.6percentt) being classified as having a meaningless response.
Thus, slight adjustments in the statistical stringency can make the pattern resemble more closely the expected "AHR-null" pattern (Fig. S3b).
This pattern resembles that in Figure S3e rather than those we considered most likely--the AHR-null pattern (Fig. S3b) or subset pattern (Fig. S3c).
A null staining pattern was observed in cases #A1, #A4 and #A8, suggesting a non-sense mutation of TP53 [ 23].
Specifically, in contrast to the null clustering pattern, the former smoker libraries are distinct from current smokers and are more similar to the never smoker cluster.
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