The widely used allele bn2, in addition to its germline defects at the restrictive temperature, is also defective in somatic development and function as glp-4 (bn2 ts )/ glp-4 null displays slow growth, protruding vulva, and bursting at the vulva.
Pericyte-deficient mutants (PDGFB-null or hypomorph and PDGFrβ-null) display systemic brain vascular leak and, postnatally, fail to establish proper polarity of the astrocyte endfeet (Armulik et al., 2010; Daneman et al., 2010b).
By contrast, chdC nulls displayed a poor growth phenotype and a large number of genes involved in mitochondrial and metabolic processes were poorly expressed exclusively in chdC nulls (Fig. 5A and supplementary material Fig. S3A).
The phyA-211 phyB-9 bas1-2 sob7-1 quadruple-null displayed the greatest germination rate, which was similar to the wild type in both dark and light treatments (P = 0.79 and 0.52 respectively).
In quantifying Wg intensity, comparative measurements showed that dfmr1 nulls displayed a significantly elevated overall abundance compared with controls (fluorescence intensity: normalized w, 1.0±0.062; dfmr1.28±0.1038±0.1.39±0.141, 1.39±0.14, P<0.05; Fig. 2B).
We find that cadherin-11 null mice display a hypoplastic synovial lining and display attenuated arthritic responses to K/BxN serum transfer arthritis.
Our studies (summarized in Table S3) show that POMCp110β null mice display hyperphagia, increased adiposity, and hyperleptinemia on normal chow diet and increased sensitivity to high-fat feeding.
Here, we show that Ret and Gfrα2 null mice display comparable early central projection deficits, but Gfrα2 null RA mechanoreceptors recover later.
Lamins A/C regulate 53BP1 levels and consequently lamin A/C-null HDF display a 53BP1 null-like phenotype.
P7 Gfra2 mutant mice show normal dorsal spinal cord (dSC) VGLUT1 staining and Gfra1 null mice display normal rapidly adapting (RA) mechanoreceptor central projections at E13.5.
Regan, C. P. et al. Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects.
