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Another way to look at this is that, if the target antigen in the LE cell were a bacterium instead of nucleus, you would say, 'Way to go, immune system.
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"This team has really pulled together, and it was the type of nucleus that you definitely want.
Does something about the nucleus nag you?
Get that critter.' Because the target is a nucleus, however, you say, 'Omigod, it's lupus.
If you have a weak point, speculatively in these brain stem nuclei, then you're going to create a heightened possibility that the development is disturbed either in anatomical arrangement or in the cell composition.
"I figured this was a long shot, and at best you might see a small effect," says Collins. "Instead, what you see, looking at the shape of the nucleus, is that you can cure these cells".
They may be less grand than Hamlet, but trust us: your caudate nucleus will thank you.
Since we wanted to be able to perform the randomization controls on all oocytes scored for colocalization, we used only images that contained one oocyte – many region 2A oocytes cannot be individually and completely cropped due to their proximity to another SC-containing nucleus, even though you can clearly distinguish between the two nuclei in 3D.
The only practical effect of hitting the jack is that is readjusts the nucleus of where you want to aim.
"But when you're part of a nucleus like this one, when you've done what we've done, that's incentive enough to come back and keep doing it again".
"It takes time to bring your own ideas into a club and bring in a nucleus of players that you believe in".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com