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The first successful implantation of electrodes capable of stimulating the auditory nucleus was reported in 1957 by French otolaryngologists André Djourno and Charles Eyriès, who embedded electrodes near the cochlear nerve of a patient who was suffering from a condition known as cholesteatoma (the growth of a cyst in the middle ear that results in hearing loss).
Twelve studies showed activation of the striatum (including putamen, accumbens nucleus, caudate nucleus) (e.g. [39], [61]), whereas thalamic activity (including pulvinar, geniculate nucleus) was reported by twelve delay conditioning studies (e.g. [48]) (for details, see Figure 2).
The caudate nucleus was reported to be involved in anticipation and performance-related feedback [ 26, 27].
Further, selective motoneuron pathology with preservation of the murine analogue of Onuf's nucleus was reported in a model of amyotrophic lateral sclerosis, intriguingly replicating the human disease (Hamson et al., 2002).
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The design, synthesis, and biological activity of novel α4β1 and α4β7 integrin antagonists, containing a bridged azabicyclic nucleus, are reported.
These findings differ from earlier pain studies using PET imaging, which have largely reported rCBF changes contralateral to the painful body-site, for example, contralateral increases in rCBF in PFC, insula cortex, and lentiform nucleus were reported following a composite third molar extraction and thermal heat pain challenge[16].
However, the translocation of Bcl-2 to the nucleus is reported to induce apoptosis.
The percentage of Ki67 positive nuclei was reported from 1,000 tumor cells within representative areas.
Finally, using MRI, in glaucoma patients a reduced size of the lateral geniculate nuclei was reported (Gupta et al. 2009).
Very recently, a process of physical transfer of DNA between nuclei was reported in Giardia cysts [ 33].
Damage to specific brainstem nuclei was reported when administering high and parenteral doses of the lipophilic artemisinin molecules arteether and artemether.
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