Sentence examples for nucleus reprogramming from inspiring English sources

One goal was to provide new hints on the process of nucleus reprogramming which takes place in vivo during early embryo development or in vitro during SCNT, and may thus help to improve the iPS technology.

Over time the proportion of the latter cells (containing two 'Purkinje-like' nuclei) increased considerably, suggesting once a BM-derived cell (with a compact nucleus) fuses with a Purkinje cell, its nucleus is reprogrammed and acquires the characteristics of a Purkinje cell.

Once inside the egg, the somatic nucleus is reprogrammed by egg cytoplasmic factors to become a zygote (fertilized egg) nucleus.

Understanding how the cell dismantles the nucleolus during cloning could help researchers understand how an adult nucleus becomes "reprogrammed" to develop as an embryo, Kikyo says.

Our results help to elucidate the mechanism by which somatic-cell nuclei are reprogrammed to have an embryo-like pattern of gene expression.

When somatic nuclei are reprogrammed with extracts from Xenopus oocytes, the level of CBX5 (heterochromatin 1α) protein in these nuclei decreases (Bian et al. 2009).

Stem cell treatments for neurological diseases also seem far away, and it all comes back to the crucial matter of reprogramming the nucleus.

One way to avoid these issues is by reprogramming the nuclei of differentiated somatic cells to a pluripotent state.

An impressive example is the observation that zygotes are capable of reprogramming somatic nuclei only after recipient cells have been arrested in mitosis [ 11], suggesting that mitosis is required for the release of reprogramming factors from chromatin to reset transcription in donor chromatin.

Moreover, the argument that the reprogrammed nucleus is anyway 'old', i.e. has the same age of the patient, appears to be at least disingenuous when compared to spared embryo derived ES cells, which are 'non-self': a reprogrammed cell should be compared to a nuclear-transferred ES cell that has exactly the same age and 'self-ness'.

Moreover, the identity of these markers is related to the tissue origin of the donor nucleus, suggesting a failure during reprogramming to silence somatic lineage genes [ 42].