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If the results hold up, "... it would allow us, in theory, to understand better phenomena within the nucleus," says Bertram Blank of the Center for Nuclear Studies in Bordeaux-Gradignan, France, including how protons inside the nucleus pair up.
However, the distances between a correct nucleus pair and an incorrect nucleus pair can be as little as a pixel or two.
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When activated in the cytoplasm, β-catenin translocates to the nucleus, pairs with LEF1 and other transcription factors, and mediates transcription of pro-survival genes including c-MYC and SURVIVIN.
Plotted are the per-nucleus or per-nucleus-pair ν estimates against the observed intensity.
The binomial and Poisson methods also produced some dramatically large per-nucleus or per-nucleus-pair estimates.
As a general hedge against such errors, we used trimmed means to estimate ν, throwing out the 10% largest per-nucleus or per-nucleus-pair estimates before averaging.
For each gene and each method, the estimates for ν are based on the per-nucleus or per-nucleus-pair estimates pooled across all embryos involving that gene.
Across genes, the correlation coefficients between the per-nucleus-pair estimates and the intensities of the siblings ranged from −0.3244 for Krüppel to 0.3944 for bicoid.
Here's another thing I've learned: when you fall in love with someone, MRI scans reveal a firework display in the caudate nuclei, a pair of shrimp-like structures located deep in the reptilian brain.
First, all the parasites were automatically cropped from the 3D images by isolating each nucleus-kinetoplast pair.
Yellow-framed expansion: mouse non-myocyte nucleus with paired-centrioles.
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