The immunoultrastructural localizations of NOTCH1, revealed by cryo-IEM, included mitochondria and nuclei, key subcellular sites of NICD1 signaling [ 45].
So for decades, molecular biologists have suspected that the way DNA folds up in the nucleus is key to making these connections at the right time and in the right place.
EMT is orchestrated in the nucleus by key transcriptional repressors, including but not restricted to, SNAIL, ZEB1 and ZEB2 [ 72].
Indeed, 11β-HSD1 (mRNandnd enzyme activity) is expressed in the hypothalamic arcuate nucleus, a key locus for appetite control [180].
In many signaling pathways, exclusion from the nucleus keeps key proteins inactive, and they are activated by nuclear import.
Previous work highlighted the cortex, striatum and cerebellum (specifically PCs and deep cerebellar nuclei) as key sites of embryonic and postnatal Foxp2 expression [9, 10].
This work has also been extended to examine liposome deposition in cardiac tissue to study the effect of liposome encapsulation on doxorubicin delivery to cardiomyocyte nuclei, the key dose-limiting organ for doxorubicin.
However, despite its interest, Jékely's idea is very difficult to test (see below) and does not provide information allowing discrimination between existing models for the origin of eukaryotes or an explanation for the origin of the eukaryotic nucleus, their key-defining character.
This text is organized around a key nucleus, This printer absolutely stinks: see Figure 19.
They lie just outside the cell's nucleus, near a key structure called the microtubule organizing complex.
