Presence of GS in newly formed corneocytes which at that time still contained many nuclei evidenced the importance of GS for functions performed by living cells.
We conclude that FACT-L is located predominantly in the parasite nucleus with evidence that a small proportion of FACT-L is located in the cytoplasm.
A full-length form of cell surface EGFR has been shown to be translocated to the nucleus, where evidence suggests that it is involved in transcriptional regulation, cell proliferation, DNA replication, DNA repair, and chemo- and radio-resistance [ 43- 48].
Using immunostaining to detect the activated form of TGF-β during estrus, they were able to show that the cells positive for active TGF-β also expressed the downstream effector R-SMAD in the nucleus, providing evidence that TGF-β acts in an autocrine manner.
Whereas eccentric nuclei are typical of healthy myofibers, fibers that contain centralized nuclei are evidence of a regenerative process, thus reflecting a state in which resident muscle satellite cells differentiate into mature myocytes that engraft within damaged myofibers to initiate repair [ 26, 27].
Concurrent with MNHEP analyses, assessments of Ki-67-positive events and the proportion of 8n nuclei provided evidence for treatment-related changes to hepatocyte proliferation.
After 8 hours of CDDO-MA (1 µM) treatment Nrf2 from cytosol translocated to nucleus as evidenced by its colocalization with the nuclear dye DAPI while Nrf2 was retained in the cytosol in DMSO controls (Figure 1B).
Additionally, methylation studies on sorted nuclei provided evidence for bidirectional methylation events in cortical neurons during the transition from childhood to advanced age, as reflected by significant increases at 3, and a decrease at 1 of 10 loci.
Like other sensory thalamic structures, the MGB is considered more than a simple relay nucleus as evidenced by recent data showing important roles for MGB neurons in coding stimulus specific adaptation and processing temporally complex stimuli [1], [2], [3].
In our study, mollugin also induced the translocation of Nrf-2 into the nucleus, as evidenced by Western blot.
