Thus exposure of RAW264.7 to ritonavir leads to its translocation to the nucleus, an event that is associated with binding of this regulatory factor to its target genes (Figure 7E), This effect was robustly attenuated by CDCA but not by gemfibrozil, indicating that FAXR and PPARα agonists act on different steps of post-translation regulation of CD36.
These effects of irradiation occur downstream of the translocation of RelB to the nucleus, an event associated with DC maturation.
When STAT3 is in dimeric form, it can translocate into the nucleus (r12, event 45) where it can carry out its specific functions (not modelled here): STAT3 binds to the DNA, activating the transcription of downstream gene targets.
Upon exposure of cells to DNA damaging agents, JNK is activated and phosphorylates 14-3-3 14-3-3 14-3-3 the resultingf c-Abl inthethe nucleus, an event released fof the induction of apoptosis in response to DNA-damaging agents [ 49].
However, even when the virus attaches to cell surface receptors, or penetrates and reaches the nucleus, these events may not always lead to completion of the viral lytic cycle.
The nucleus of an event is the process realized by the VG.
The event nucleus is constructed from a preparatory phase, a culminating event and a consequent phase.
A useful notion for distinguishing Aktionarten is the event nucleus introduced by Moens and Steedman (1988).
In addition, confocal microscopy revealed that some single cells had nuclei with abnormal content which may have resulted from a fusion event (nucleus with one Y and several X chromosomes) (data not shown).
Following estrogen stimulation, both receptors migrated to the nucleus, a crucial event to trigger target gene transcription via the genomic pathway of the estrogen signaling cascade.
