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For example, we can consider classes such as nucleus class, Golgi class, mitochondrion class, etc., for cell image segmentation.
Unlike class I HDACs, which are predominantly localized in the nucleus, class II HDACs actively shuttle between the cytoplasm and nucleus being under control of classic cellular signaling pathways, and cellular localizations represents a fundamental mechanism for them [ 12, 14].
The classical HDACs are Zn2+ dependent enzymes: class I HDACs (HDACs 1, 2, 3, and 8) share homology to the yeast HDAC Rpd3 and are localized to the nucleus; class II HDACs are related to yeast Hda1 and shuttle between the cytosol and nucleus (HDAC 4, 5, 7, 9) or reside in the cytosol (HDAC 6, 10).
As described by Kobayashi et al. [ 19], 100 cells per animal were analyzed, and comets were classified as follows: (class 0) undamaged cells with no tail, (class 1) cells with a tail smaller than the diameter of the nucleus, (class 2) cells with a tail length one to two times the diameter of the nucleus and (class 3) cells with a tail length greater than two times the diameter of the nucleus.
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Class I HDACs mostly are found in the cell nucleus, whereas class II HDACs can be localized in the cytosol and/or nucleus.
Chapter sections contain about the right amount of material to form the nucleus of one class period.
Tumours exhibiting ⩾5% positive nuclei were classed as p63 positive (Cho et al, 2003).
6,078 nuclei were classed as ON (2444) or OFF (3634) depending on whether eve's expression is above or below the threshold of 0.2 (approximately 20% of maximum).
In terms of localization based on bioinformatics, AtHDA2 may similarly be exported out of the nucleus just like Class II HDAs due to the presence of multiple NES.
The HDAC family has four major classes, with class I (nucleus), II (nucleus and cytoplasm), and IV requiring the zinc ion for catalytic activity.
Proteins representing diverse functions are transported into the nucleus and include classes of transcriptional regulators, which form a complex network and direct plant immune responses through transcriptional reprogramming [ 11].
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