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The number of neutrons in a nucleus affects the mass of the atom but not its chemical properties.
Second, the spatial distribution of the protons in the nucleus affects in measurable ways the behaviour of the surrounding electrons.
Semiempirical calculations of the intercalation complexes show that the isosteric replacement of a benzene ring in the acridine nucleus affects not only DNA affinity but also base pair selectivity.
How the pattern of chromosomes and subnuclear bodies in the cell nucleus affects gene activity and other cellular functions is an enduring mystery in biology, one that won't be unraveled soon.
The positioning of the nucleus affects the proliferation, migration and differentiation of neurons (Higginbotham and Gleeson, 2007; Morris et al., 1998; Zhang et al., 2009).
It is therefore necessary to elucidate whether and how the physical structure of the nucleus affects the dynamics and access of proteins.
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Any factors that change the magnetic field strength experienced by the nucleus affect the energy at which absorption occurs.
This may regulate interaction of maspin with its binding partners which in turn, depending on their function and modifications, may translocate to and from the cell nucleus, affecting maspin location.
While we were unable to measure progesterone or prolactin in this study, it is possible that RFRP projections to the arcuate nucleus affect dopaminergic signaling required for prolactin release and maintenance of progesterone levels and pregnancy success.
Therefore, not all editing events in pre-miRNA in the cytoplasm necessarily disrupt Dicer processing just as not all editing events in pri-miRNA in the nucleus affect Drosha cleavage.
Delayed induction of P-gp expression includes signaling via TNF-α [ 229] and ET-1, but in this case a signaling cascade activates nuclear factor-κB (NF-kB), which is a ubiquitous transcription factor that controls the expression of genes; NF-kB then translocates to nucleus affecting gene expression [ 230].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com