The ribozyme cleavage sites were selected through homology comparison of all known murine GABAA receptor subunits at the amino acid and nucleotide sequence level.
The characterization of a considerable number of rearrangement breakpoints has now been accomplished at the nucleotide sequence level, thereby providing an invaluable resource for the detailed study of the mutational mechanisms which underlie genomic recombination events.
We then compared members of each Group at the nucleotide sequence level.
The limited variation for the nucLSU rRNA and mtSSU rRNA sequences is likely due to their functional constraint at the nucleotide sequence level.
Also, the lost cysteine residues were always in pairs, despite being distantly separately at the primary nucleotide sequence level in their genes (Figure 1).
This similarity is also reflected at the nucleotide sequence level (Fig. 5C), suggesting strongly that recombination occurred between ∼50 bp sequences to yield the observed structures.
This is mainly because cross-species comparison is normally performed on the amino acid sequence level but not at the nucleotide sequence level (because of the high variation of nucleotide sequences for ortholog genes between species during evolution).
Hence we conclude that the genomes of both influenza viruses and their hosts share a common evolutionary selection pressure at the nucleotide sequence level to eliminate CpGs in an AU context.
Ultimately, using these methods, it was possible to deduce the structure of most of the dicentric GCRs analyzed, although we did not determine the structure of all of these GCRs to the nucleotide sequence level.
Mycobacteriophage Hope is a member of Cluster G and all of the Cluster G phages, BPs, Halo, Angel, and Hope are extremely similar at the nucleotide sequence level [8].
Although any two humans are 99.9% identical at the nucleotide sequence level [1], [2], many phenotypic differences are apparent in individuals within the same and from distinct human populations.
