Sentence examples for nucleotide polymerase from inspiring English sources

One question is whether the troubles with BMS-986094 will extend to other drugs in its class, known as nucleotide polymerase inhibitors.

Patients with chronic hepatitis C virus (HCV) infection have high rates of sustained virologic response (SVR) after 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor velpatasvir.

Last week, Idenix Pharmaceuticals said the Food and Drug Administration placed a hold on a trial of its nucleotide polymerase inhibitor, IDX184, because of the heart failure case in the Bristol-Myers trial.

All patients received ledipasvir, an NS5A inhibitor, and sofosbuvir, a nucleotide polymerase inhibitor, as a single fixed-dose combination for 12 weeks.

Patients were randomly assigned in a 1 1 1 ratio to receive the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor velpatasvir once daily for 12 weeks, sofosbuvir-velpatasvir plus ribavirin for 12 weeks, or sofosbuvir-velpatasvir for 24 weeks.

Hepatitis C virus (HCV) treatment took a major step forward at the end of 2013 with the approvals of the second-generation protease inhibitor simeprevir (Olysio) and the nucleotide polymerase inhibitor sofosbuvir (Sovaldi).

Prior studies have revealed a relatively complex link between polymerase rate and error rate for nucleotide polymerases [12].

Template dependent nucleotide polymerases use a remarkably well conserved two metal ion dependent phosphoryl transferase mechanism for nucleotide addition.

A cursory look at the active site mechanism of known nucleotide polymerases makes it trivial to reject this possibility.

Another way to analyze these experiments is to look at the way that the rate of the nucleotide polymerases evolves at each temperature.

Each microtiter plate well contained a 20-μL mixture of the following: 10 μL 1X iQ SYBR Green Supermix, which contained all the nucleotides, polymerase, reaction buffer, and SYBR green dye (Bio-Rad, Hercules, CA), 5 μL forward and reverse primers, giving final optimal concentrations of 300 nM for each, and 5 μL of DNA as template (2.5 ng per well).