Sentence examples for nucleotide editing from inspiring English sources

Interestingly, we observed profound nucleotide editing of "seed" and flanking sequences of miRNAs during cortical development.

Vif enhances HIV-1 infectivity by blocking the antiviral activity of the nucleotide editing enzyme APOBEC3G [ 15].

Biologically, as a result of junctional recombination, P/N nucleotide editing and somatic hypermutation (for BCR/antibodies) [ 14], the protein sequence space of CDR3s is immense and renders the finding of significant overlap between repertoires highly unlikely.

We demonstrated dynamic and stage-specific expression of a large group of known miRNAs, with surprisingly profound nucleotide editing at "seed" and flanking sequences of miRNAs during cortical development.

However, analysis of cDNA reveals evidence of expression by functional TRB chains of TRBD1in the reading frame that doesn't encode a glycine but have generated a glycine codon by nucleotide editing at the VJ junction (data not shown).

In addition, three sites predicted as edited by PREP-Mt show heterogeneity among taxa in their editing status (e.g., C nucleotides edited in some species but not in others).

The topology of the maximum likelihood tree based on the nucleotide alignment edited with Gblocks [ 56] (including 6,839 positions) differs from that based on the alignment edited with ALISCORE only with regard to nodes that are not well supported in any of the trees (Additional file 4).

Two distinct applications, gene disruption and single-nucleotide gene editing, were demonstrated, highlighting the versatility of this approach.

The distribution of nucleotides around editing sites in lower and higher plant chloroplasts was examined within codons, and a detailed analysis of the effects on codon changes and usage was developed (Tillich et al. 2006), and a model for the evolution of RNA editing based on conservation of codon usage was proposed.

The topology of the maximum likelihood tree based on a direct nucleotide alignment (edited with ALISCORE; including 12,648 positions; Additional file 5) does not differ from that based on the nucleotide alignment derived from the amino acid alignment in any strongly supported nodes.

Similar to alteration of nucleotides by RNA editing, single nucleotide polymorphisms (SNPs) and point mutations within the pri-miRNA have the potential to alter the secondary structure and prevent processing of the pri-miRNA.