Sentence examples for nucleotide backbone from inspiring English sources

We therefore postulated that by manipulating the nucleotide backbone and fine tuning the duplex stability through modified nucleotide chemistry, it may be possible to significantly modulate many characteristics of the system, such as binding affinity, specificity, stability, in vitro and cellular activity, which would be crucial for development of efficacious CRISPR-based therapeutic entities.

BPCR has the potential to be developed into a method for the detection of nucleotide backbone interruptions or other factors that impede 3' extension by polymerase.

The role for non-specific binding residues is to stabilize the interactions between protein and nucleotide backbone to help specific binding residues in recognizing base pairs correctly.

16 GS-103, a controlled Phase III clinical trial compared the safety and efficacy of atazanavir boosted with cobicistat (n=353) versus ritonavir (n=355) in HIV-1-infected patients, both receiving emtricitabine/tenofovir-DF as a nucleotide backbone, over 48 weeks on treatment.

To overcome stability problems, chemical modifications such as phosphorothioate or methyl phosphonate are often applied to the nucleotide backbones [ 15].

This situation points to electronic and topologic nucleotide's backbone interactions control of the stability profile of paromomycin RNA complexes.

However, because of the relative tolerance to modifications of the upstream sequence (Miller et al, 2008), the interaction could rely partly on contacts with the nucleotide's backbone.

In myosin, the equivalent structural region undergoes substantial β-sheet flexure on nucleotide release (backbone RMSD > 3.2 Å, Figure 5 figure supplement 1D; Coureux et al., 2003; Reubold et al., 2003).

Proper folate concentration is important for the synthesis of DNA nucleotides, the backbone of DNA, in which desoxyuridylate monophosphate (dUMP) is changed to thymidylate monophosphate (TMP) by thymidylate synthase using 5,10-methylene-THF as a methyl donor.

A ClustalW analysis of their backbone nucleotide sequences shows that their sequence identity is not uniform among the different genome regions.

Pseudorotation restraints were also used, but with the exceptions of the terminal bases C, G, C, G, and the modified nucleotides R or S. For unmodified nucleotides, empirical phosphodiester backbone angles were restrained by square well potentials with widths of ±60°.