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The immunoultrastructural localizations of NOTCH1, revealed by cryo-IEM, included mitochondria and nuclei, key subcellular sites of NICD1 signaling [ 45].
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Second, serotonin neurons project to the key hypothalamic nuclei responsible for the regulation of appetite, energy expenditure and bone mass [ 15].
The ability to generate cells lacking nuclei and centrosomes (SPBs) is key to the elucidation of the role of these structures in various cellular processes.
A few years later the key discovery that nuclei in chemically distinct sites in the same molecule resonate at slightly different frequencies was reported (Dickinson, 1950; Proctor and Yu, 1950), which led to the important application of NMR in the field of analytical spectroscopy.
Aberrant nuclei refer to nuclei with abnormal morphology, such as fragmented nuclei or nuclei with irregular shapes.
The aggregation of MNs that connect to the same target muscle into nuclei and motor pools is a key event in early MN development and depends on MN subtype-specific expression of cadherins (Bello et al., 2012; Demireva et al., 2011; Price et al., 2002).
Generally, in ED process, the seed layer plays a key role because it offers nuclei sites which allow the ZnO nanostructures to grow densely [10].
In addition, co-treatment with ABT-737 and cafestol increased chromatin damage in the nuclei and cytoplasmic histone-associated DNA fragmentation, indicating the key characteristic of apoptosis.
A surprisingly high frequency of unclassifiable MPN (23 28% compared with 10 15% or even less in other studies), an incomplete description of megakaryocyte nuclei atypia (failure to include clumsy/cloud-like abnormalities as key feature of atypia), but particular a very low reproducibility of fiber grading was in sharp contrast with previously reported findings.
Neuropeptide signaling plays key roles in coordinating cellular activity within the suprachiasmatic nuclei (SCN), site of the master circadian oscillator in mammals.
Modern alternative classification systems generally begin with the three-domain system: Archaea (originally Archaebacteria); Bacteria (originally Eubacteria) and Eukaryota (including protists, fungi, plants, and animals) These domains reflect whether the cells have nuclei or not, as well as differences in the chemical composition of key biomolecules such as ribosomes.
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