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However, mitosis appeared to be comparatively unaffected as DNA replication and nuclear segregation were essentially normal.
One spindle positioning pathway can rescue the other, but inactivation of both Kar9p and dynein pathways impairs nuclear segregation and is lethal [14].
In conclusion, double mutants SA/dyn1Δ and SA/kar9Δ exhibited many errors in nuclear positioning and nuclear segregation, with the apparition of polyploid cells.
Morphological defects encompassing both the ER and cell body, defective cytokinesis and nuclear segregation and internal accumulation of VSG were frequent.
This may be due to a functional redundancy in nuclear segregation by dad5 + and SPAC11D3.06.
Many of cell divisions driven by protrusion formation were accompanied by nuclear segregation.
Similar(33)
In all trypanosomatids, the nuclear chromosomal segregation takes place during a closed mitosis, with formation of an intranuclear spindle without disruption of the nuclear envelope [25].
Fission yeast skp1 is required for spindle morphology and nuclear membrane segregation at anaphase [ 48].
Different types of radiation can cause nucleolar segregation, nuclear relocation of proteins, and changes in protein post-translational modifications [ 4, 6, 8, 23– 28].
S phase is followed by chromosomal segregation, nuclear division and cell division, which is collectively called M phase.
On the one hand, Presgraves (2007) suggested that accelerated evolution of Nups may be related to nuclear transport-related segregation distortion.
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