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Histone acetylation is a significant epigenetic modification in embryo development and nuclear reprogramming.
Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type.
HDACi is a widely used epigenetic modifier in cancer treatment and somatic cell nuclear reprogramming such as SCNT and iPSCs derivation.
Nuclear reprogramming is critical for animal cloning and stem cell creation through nuclear transfer, which requires extensive remodeling of chromosomal architecture involving dramatic changes in chromatin-binding proteins.
Nevertheless, chromatin states can be reversed through nuclear reprogramming.
Nuclear reprogramming of somatic cells is a promising route in cell replacement therapy that can be used to replace or restore normal function of damaged cells.
Nuclear reprogramming enables patient-specific derivation of induced pluripotent stem (iPS) cells from adult tissue.
The identity of somatic cells can also be reversed experimentally by nuclear reprogramming.
Nuclear reprogramming is characterized by a global shift in gene expression.
Nuclear reprogramming is of interest because it reverses what is normally a highly stable state of cell differentiation.
Nuclear reprogramming experiments reveal the mechanisms required to activate embryonic gene expression in adult cells and thus provide insight into the reversal of epigenetic memory.
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