Originally, gun mutants were isolated for their deficiency in nuclear gene repression following chloroplastic damage [51], and are therefore assumed to be affected in chloroplast to nucleus signalling.
Thus, these data provides strong evidence consistent with nuclear BNIP3 repression of the expression of the DR5 gene in GBM tumors.
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It has however become clear that an important regulatory activity of nuclear receptors involves repression of genes in response to regulatory ligands [3] [5].
SOP-2 sumoylation is required for in vivo localization to nuclear bodies and repression of HOX genes [ 30].
This work consolidates our previous findings that aspirin-induced apoptosis occurs after I κB degradation, NF κB nuclear translocation and repression of NF κB-driven transcription.
We found that aspirin treatment induced apoptosis following I κB α degradation, NF κB nuclear translocation and repression of NF κB-driven transcription, irrespective of p53 and DNA MMR status.
We observed a dose-dependent increase in apoptosis after treatment with aspirin following I κB α degradation, NF κB nuclear translocation and repression of NF κB-driven transcription in both cell lines.
The various subunits of the Caf1-CCR4-Not complex functionally contribute in different ways, including deadenylation of transcripts, RNA processing, nuclear export, translational repression and feeding into the DNA damage response [ 91, 93, 94].
The microscopic analysis of fluorescence in different carbon sources, including various simple and complex polysaccharides, non-polysaccharides and carbon starvation, assisted in the understanding of the signals involved in CreA nuclear localisation and repression.
