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The nuclear relocation was confirmed by the immunodetection of MLP on the nuclear and cytosolic fractions.
By inducing RNA-chromatin binding a number of RNA-dependent activities can be dissected: (i) The RNA-induced compaction or decondensation of chromatin, (ii) identification of RNA-interacting chromatin modifiers that set epigenetic signals such as posttranslational histone modifications, and (iii) nuclear relocation of a genomic locus targeted by the tethered RNA.
In contrast, mutation at Thr-469 did not impair NIK-mediated nuclear relocation of rpL10 or tolerance against geminivirus.
We also established that doxorubicin treatment induces proliferation arrest and FOXO3a nuclear relocation in sensitive breast cancer cells.
Furthermore, mutations at Thr-474 and Thr-469 residues antagonistically affected NIK-mediated nuclear relocation of the downstream effector rpL10.
The observations suggest that nuclear relocation of WOX1, JNK1 and transcription factors is a p53-independent event.
Similar(41)
Here, synthetic MAPK substrates were engineered to undergo nuclear-to-cytoplasmic relocation upon phosphorylation of a nuclear localization sequence.
Since nuclear relocation of GFP bZIP28 was not observed in TRV protoplasts or TRV epidermal cells, these results suggest that NbNAG deficiency activates the ER stress response.
This paper presents the results of dose and cost calculation for relocation after nuclear accidents.
Mehta, I. S., Amira, M., Harvey, A. J. & Bridger, J. M. Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts.
But with tensions in the region at boiling point over the Syrian civil war, the disintegration of the Iran nuclear deal, and the relocation of the American embassy to Jerusalem Monday, few expect this to be the end of the matter.
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