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However, ASA proved unable to affect its nuclear recruitment.
In addition, our experiments indicate that any factors triggering nuclear recruitment of centrosome proteins must have been restricted to the differentiated H-2Kb-tsA58 cell prior to fusion, since no perinuclear accumulation of centrosome proteins was seen in unfused human U2OS cells or in undifferentiated myoblasts.
For SRF, we noted no nuclear recruitment after MuRF1/2 deletions.
Collectively, these findings support impaired nuclear recruitment of HDAC2 as a potential mechanism of steroid-resistant neutrophilic airway inflammation in asthma.
In this report we present evidence that the nuclear recruitment of the SYT-SSX2 oncogene is a non-random event and that it is directed to specific loci across the genome.
As reported in Figure 5b, a significant amount of FOXO1 protein accumulated in the nuclei of PGC-1 α cells already at day 0, and differentiation further enhanced its nuclear recruitment.
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These differences will be important as ligands are designed that lead to specific patterns of nuclear receptor recruitment of corepressors.
The intra-molecular interaction between the kinase domain and the PBD might thus inhibit nuclear import, recruitment to the target sites, and kinase activity.
The authors proposed that Pab2p promotes poly(A) tail trimming from pre-snoRNAs through nuclear exosome recruitment.
In summary, the timing of nuclear membrane recruitment to chromatin is regulated by the reversal of mitosis-specific phosphorylation events on nuclear membrane proteins.
Spatial organization by the ran system might contribute to nuclear membrane recruitment by exposing DNA-binding domains of membrane proteins in the vicinity of chromatin but the relevance of such a mechanism has not been determined.
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