Refinements in instrumentation (both in nuclear and non-nuclear modalities) and improvements in image analysis should allow us to combine the strengths of the different modalities to better measure in vivo biology.
The American Academy of Orthopaedic Surgeons AAOSS) could give only a weak recommendation for nuclear imaging modalities in the diagnosis of periprosthetic joint infections [11].
Hybrid nuclear imaging modalities require a correct description of the acquisition geometry for accurate reconstruction and co-registration of images.
In parallel, nuclear imaging modalities generate a signal that combines high sensitivity (up to 10E − 12 mol/l), with quantitative 3D possibilities, when using adequate scatter and attenuation corrections [[3] [5]].
During the past decade, numerous radiolabeled EGFR-targeted agents, namely antibodies and TKIs, have been investigated as probes for visualizing and quantifying EGFR expression in tumors using nuclear imaging modalities, such as single photon emission computed tomography (SPECT) and PET [16-29].
The combination of MRI with nuclear imaging modalities such as positron emission tomography (PET) or single photon emission computed tomography (SPECT) increases the data available from a single diagnostic scan (e.g. quantification, multiple image overlay).
To overcome this, nuclear imaging modalities can be co-registered and overlaid with conventional CT or MRI imaging, hence providing anatomical landmarks in relation to molecular information.
Y. Zhu and his coauthors summarize the molecular and functional imaging findings on neurobiological mechanisms of IA, focusing on magnetic resonance imaging (MRI) and nuclear imaging modalities including positron emission tomography (PET) and single-photon emission-computed tomography (SPECT).
This review summarizes molecular and functional imaging findings on neurobiological mechanisms of IA, focusing on magnetic resonance imaging (MRI) and nuclear imaging modalities including positron emission tomography (PET) and single photon emission computed tomography (SPECT).
A triple fusion (TF) reporter gene, truncated tk-egfp-fl, was constructed to visualize the TF-transduced cells in living animals by optical, fluorescent, and nuclear imaging modalities [ 10].
We also describe the strategy, design, and utilization of these peptides as potential radiopharmaceuticals as their combination with nuclear medicine modalities such as SPECT or PET would allow noninvasive whole-body examination for detection of occult infection causing, for example, fever of unknown origin.
