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The architecture of the well-organized nuclear functional domains changes in response to DNA replication, RNA transcription, processing and transport dynamics.
The nucleolus has been proposed as the paradigm of nuclear functional compartmentalization (Strouboulis and Wolffe 1996).
These technologies applied to nuclear dynamics have introduced new dimensions and unexpected concepts concerning nuclear functional compartmentation.
Therefore, it is possible that FGFR1 and a pool of FGF2 may influence distinct nuclear functional domains in PSCs.
Furthermore, expression at the mRNA level does not necessarily mean nuclear functional activity, because Snail could be localized in the cytoplasm.
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Because mtDNA introgression and gender-based dispersal were ruled out, we hypothesized that mtDNA spatial division was maintained by mito-nuclear functional compensation.
This new concept targets more of a disease management approach rather than the usual division into the medical specialties of radiology (anatomical imaging) and nuclear medicine (functional imaging).
This is mediated by a functional nuclear localization signal (NLS) and nuclear export signal (NES) within the REKLES region [17].
SHARP-2 is known to possess a functional nuclear export sequence (NES) and two nuclear localisation signal (NLS) motifs [ 46].
Moreover, processing of CD43 by γ-secretase results in a CD43 cytoplasmic tail fragment, containing a functional nuclear localization sequence interacting with the nuclear transporter protein Ran.
Little is known about their direct host targets; some have a functional nuclear localization signal (NLS) suggesting a nuclear target [ 5].
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