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We also observed a significant reduction in the number of DMPK mRNA-containing nuclear foci in human DM1 myoblasts.
RAD51 regulates BRCA1 and BRCA2 in HR and localizes BRCA1 in the nuclear foci during the S and G2 phases of the cell cycle [40].
In both pathologies the mutant RNA forms nuclear foci.
These data demonstrate that although nuclear foci are not sufficient to produce a DM1 phenotype, in all cases in which DM1 pathology develops nuclear foci are observed.
XopD is localized in nuclear foci indicating that host targets are likely nuclear SUMOylated proteins [43].
CG9650 RNA co-localizes with the CUG expansion in the nuclear foci.
It is universally expressed and co-localised with BRCA1 in nuclear foci [7].
Of note, this occurred simultaneously with depletion of BRCA1 from nuclear foci (Fig. 1A. bottom panel).
We noted that p19ARF localized to only one to two distinct nuclear foci within BXB11 adenomas.
In addition, pRB localizes to internal nuclear foci enriched in lamin A/C [5].
Mcl1 forms S-phase-specific nuclear foci, which colocalize with those of PCNA and Polα.
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