Mr. Roshan was at least the fifth Iranian scientist with nuclear connections to be killed since 2007.
He has also helped it build secretive underground tunnels.A North Korean list devoid of all outside nuclear connections would be one damaging development; full disclosure could be another sort of bombshell.
He was at least the fifth scientist with nuclear connections to be killed since 2007; a sixth scientist, Fereydoon Abbasi, survived a 2010 attack and was put in charge of Iran's Atomic Energy Organization.
Nuclei appeared to be carried into the protrusion by cytoplasmic flow, though it is possible that endoplasmic reticulum based nuclear connections to the plasma membrane could also contribute to nuclear segregation (Fig. 6; supplementary material Movie 11).
The PCs of a specific microzone in turn have a specific innervation territory in the AIP [18], [19], [20], [21], [22], and the specificity in the olivo-cortico-nuclear connections forms the basis for the microcomplex organization of the cerebellar cicruitry [20], [22], [23], [24], [25].
Early insights into cytoskeletal-nuclear connections came from studying nesprins in lower organisms such as Caenorhabditis elegans and Drosophila melanogaster, which both only posses one nesprin-1/-2 homologue; ANC-1 and MSP-300 respectively.
Amongst the many nuclear basket connections are the transcriptional apparatus, the lamina and protein/RNA transport systems.
The dynein-nuclear envelope connection in mammalian cells is mediated by three nonredundant molecular linkages and is required both for the attachment of the centrosomes to the nucleus and for their proper separation during prophase (Splinter et al. 2010; Bolhy et al. 2011; Jodoin et al. 2012).
Outside-in models account for the nuclear-ER connection, but new assumptions need to be added to account for ER continuity, for the lack of similarity between the S-layer and eukaryotic cell walls, for N-linked glycosylation machinery having been relocalized from the plasma membrane (S-layer) to the ER, for the fusion of vesicles to form a single nucleus that lacks functional ribosomes, and so on.
