"nuclear compartmentalization" is a correct and usable phrase in written English.
It can be used to describe the process or state of organizing or dividing the components of a nuclear structure. Example: "The cell's nuclear compartmentalization allows for precise regulation and control of gene expression."
The study of nuclear compartmentalization of GSH poses a significant methodological challenge and the findings were controversial over the last decade.
We propose that alteration of nuclear compartmentalization might represent an additional common mechanism of leukemogenesis.
Armelin-Correa, L. M., Gutiyama, L. M., Brandt, D. Y. & Malnic, B. Nuclear compartmentalization of odorant receptor genes.
The interconnection between the functionally dependent architecture of the interphase chromosome and nuclear compartmentalization is also discussed.
Computational analyses of these genome mapping data from several cell types will be aimed at identifying possible cis- and trans-determinants of nuclear compartmentalization.
If nuclear dysfunction represents an important etiopathological feature in neurodegenerative disease, then this should be reflected by functional and/or morphological alterations in this nuclear compartmentalization.
Finally, it is possible that adjacent gene co-regulation may be mediated, in part, at the level of sub-nuclear compartmentalization. High resolution mapping of gene localizations in yeast revealed that transcriptionally active sets of genes, including those involved in ribosome biogenesis, occupied specific nuclear territories at the nucleolar periphery upon activation [ 43].
The nucleolus has been proposed as the paradigm of nuclear functional compartmentalization (Strouboulis and Wolffe 1996).
Similarly, the cdc24-4 mutation did not affect nuclear envelope compartmentalization at room temperature (BI = 9.1 ± 2.4 for Nsg1, Figure 4B).
Moreover, as Tpr is attached to the NPCs of many vertebrate cell types of different germ-layer origin (Cordes et al, 1997; Kuznetsov et al, 2002), these cells may likewise possess NB-like structures, thus representing a near-ubiquitous tool of nuclear-peripheral compartmentalization.
Chromatin dynamics control nucleosome assembly and higher order chromatin structure, and are responsible for the global nuclear organization and compartmentalization, tightly regulating gene expression and controlling protein-DNA interactions within the cell nucleus [ 37, 38].
