Though their short sharp yelps were resounding, indicating they had bayed a hog, Fire and Nub had failed to summon the other dogs.
As a positive control, we analyzed the expression of CecA1-lacZ in flies in which nub had been down-regulated by RNAi in the fat body c564-Gal44; UAS-dsnub).
More recently, immunostaining of Nub protein has been used as an enterocyte cell marker in the adult midgut [ 29], but the role of nub in these cells has not been defined.
The nub gene has been extensively studied for its roles in embryonic development, in differentiation of the central nervous system [ 21- 24], and for normal growth and patterning of wings and legs [ 20, 25- 28].
Only nub-13 has a single but extended Hunchback/Castor DNA-binding motif (CATAAAAAA/TTTTTATG, Fig. 10b), which has a greater similarity to the consensus sequence [ 3, 13, 14] than does the 6-mer.
Similar to mammalian Oct1/2 transcription factors, Nub-PD has been shown to bind with high affinity to the Oct consensus motif (ATGCA/TAAT) and to several closely related motifs [ 37- 39] as well as more divergent non-Oct motifs [ 40].
Eh? Look, she says, it's a long story, but here's the nub: she had always wanted to go to Cambridge, always wanted to study English, and it all seemed to fall into place too easily.
Built with arguably the best laptop keyboards in the business, along with their industry bellwether red trackpoint nub, ThinkPads have gone through a few iterations of design signatures while maintaining the same tenants of ergonomics and usability for the business world.
A higher quality press has nubs on it that make clearing garlic out of the holes easier, and you might be able to get more garlic out of each clove as a result.
Her baby, on the other hand, barely even has a nub on her little face.
